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About CCA!
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Voiceover
Now let's look at a cleavage enzyme that might play an important role in the treatment of AIDS.
HIV has a vital cleavage enzyme called HIV-1 protease. The protease helps create all the proteins you saw in the virus model and like any enzyme is a protein itself. Active protease has two identical protein molecules called monomers.
The monomers are attracted to each other and to special cleavage sites on the pre-protein. These attractions result in a structure called a dimer.
Flexibility of the monomers can be seen in the flickering green ribbons in this dynamic simulation. This flexibility allows the monomers to dock with each other and with the pre-protein cleavage sites.
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Citation:
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Jacobsen, E. B.; Jacobsen, J. J.; Wright, J. M.
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J. Chem. Educ. Software HIV-1 Protease: An Enzyme at Work SP13
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Creator:
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Erica Bode Jacobsen
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University of Wisconsin - Madison, Madison, WI 53706
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Executive Producers:
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John W. Moore
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University of Wisconsin - Madison, Madison, WI 53706
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Clark R. Landis
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University of Wisconsin - Madison, Madison, WI 53706
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Support:
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National Science Foundation
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Directorate for Education and Human Resource
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Science Education Scholars Program
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University of Wisconsin - Madison, Madison, WI 53706
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Institute for Chemical Education
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University of Wisconsin - Madison, Madison, WI 53706
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Project Seraphim
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University of Wisconsin - Madison, Madison, WI 53706
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Science Education Advisor:
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Julie Jensen
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Middleton High School, Middleton, WI 53562
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Scientific Support:
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Daniel H. Rich
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University of Wisconsin - Madison, Madison, WI 53706
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Kenneth Satyshur
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University of Wisconsin - Madison, Madison, WI 53706
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Jean-Yves Sgro
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University of Wisconsin - Madison, Madison, WI 53706
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HIV Virion Animation:
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Saviz Artang, George V. Kelvin
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(c) Scientific American Inc. Used by permission
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Writers:
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Erica Bode Jacobsen
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University of Wisconsin - Madison, Madison, WI 53706
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J. Monty Wright
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University of Wisconsin - Madison, Madison, WI 53706
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Kelly Houston Jetzer
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University of Wisconsin - Madison, Madison, WI 53706
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Jerrold J. Jacobsen
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University of Wisconsin - Madison, Madison, WI 53706
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Animation:
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J. Monty Wright
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University of Wisconsin - Madison, Madison, WI 53706
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VISUALITY
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5010 Flambeau Road, Madison, WI 53705
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Video production, editing, and voice:
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Jerrold J. Jacobsen
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University of Wisconsin - Madison, Madison, WI 53706
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Greg Minix
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University of Wisconsin - Madison, College of Engineering, Madison, WI 53706
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Kelly Houston Jetzer
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University of Wisconsin - Madison, Madison, WI 53706
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