Gibbs free energy

Does ATP Provide Energy?

When using standard thermodynamic values, the chemical reaction whereby ATP is converted to ADP is found to have a positive value for ΔG. This would imply the reaction REQUIRES energy. However, analyzing the process under physiological conditions shows that ΔG is in fact negative, as expected.

Gibbs Free Energy Analogy

A common topic in chemistry discussion groups and forums is about the use of the terms “spontaneous reaction” versus “thermodynamic favorability”. This is a new activity for chemistry students who struggle with the correlation between changes in enthalpy, temperature, entropy, and the Gibbs free energy of a system; which relies on an analogy that most students will be familiar with.