There are some simple ways to break chemical bonds with microscale techniques.
I tend to enjoy acid base titrations for several reasons. First, students get to work with burettes, acids, bases and they see a nice "color change" when they reach an endpoint. Many times, students who tend to struggle with pen and paper testing excel at the "hands-on" approach. Titrations also dovetail well with stoichiometry which provides a nice review of information closer to the end of the year.